1lpw: Difference between revisions

Revision as of 21:46, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1lpw.png

Template:STRUCTURE 1lpw

Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridineSolution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine

Template:ABSTRACT PUBMED 12426583

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine., Newby MI, Greenbaum NL, Nat Struct Biol. 2002 Dec;9(12):958-65. PMID:12426583

Page seeded by OCA on Wed Jul 2 21:45:59 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1lpw.gif|left|200px]]
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-'''Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine'''
+===Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine===
-==Overview==
+<!--
-Pairing of a consensus sequence of the precursor (pre)-mRNA intron with a short region of the U2 small nuclear (sn)RNA during assembly of the eukaryotic spliceosome results in formation of a complementary helix of seven base pairs with a single unpaired adenosine residue. The 2' OH of this adenosine, called the branch site, brings about nucleophilic attack at the pre-mRNA 5' splice site in the first step of splicing. Another feature of this pairing is the phylogenetic conservation of a pseudouridine (psi) residue in U2 snRNA nearly opposite the branch site. We show that the presence of this psi in the pre-mRNA branch-site helix of Saccharomyces cerevisiae induces a dramatically altered architectural landscape compared with that of its unmodified counterpart. The psi-induced structure places the nucleophile in an accessible position for the first step of splicing.
+The line below this paragraph, {{ABSTRACT_PUBMED_12426583}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12426583 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12426583}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
 ==Reference==
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 [[Category: Pseudouridine]]
 [[Category: U2 snrna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:09:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 21:45:59 2008''