2qh4: Difference between revisions

Revision as of 21:26, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2qh4.png

Template:STRUCTURE 2qh4

Solution structure of the U85 C/D-H/ACA scaRNA 5' terminal hairpin loopSolution structure of the U85 C/D-H/ACA scaRNA 5' terminal hairpin loop

Template:ABSTRACT PUBMED 17889661

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

Structural and functional characterization of human telomerase RNA processing and cajal body localization signals., Theimer CA, Jady BE, Chim N, Richard P, Breece KE, Kiss T, Feigon J, Mol Cell. 2007 Sep 21;27(6):869-81. PMID:17889661

Page seeded by OCA on Wed Jul 2 21:26:33 2008

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OCA

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-[[Image:2qh4.gif|left|200px]]
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 {{STRUCTURE_2qh4|  PDB=2qh4  |  SCENE=  }}
-'''Solution structure of the U85 C/D-H/ACA scaRNA 5' terminal hairpin loop'''
+===Solution structure of the U85 C/D-H/ACA scaRNA 5' terminal hairpin loop===
-==Overview==
+<!--
-The RNA component of human telomerase (hTR) includes H/ACA and CR7 domains required for 3' end processing, localization, and accumulation. The terminal loop of the CR7 domain contains the CAB box (ugAG) required for targeting of scaRNAs to Cajal bodies (CB) and an uncharacterized sequence required for accumulation and processing. To dissect out the contributions of the CR7 stem loop to hTR processing and localization, we solved the solution structures of the 3' terminal stem loops of hTR CR7 and U64 H/ACA snoRNA, and the 5' terminal stem loop of U85 C/D-H/ACA scaRNA. These structures, together with analysis of localization, processing, and accumulation of hTRs containing nucleotide substitutions in the CR7 domain, identified the sequence and structural requirements of the hTR processing and CB localization signals and showed that these signals are functionally independent. Further, 3' end processing was found to be a prerequisite for translocation of hTR to CBs.
+The line below this paragraph, {{ABSTRACT_PUBMED_17889661}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17889661 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17889661}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH4 OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QH4 OCA].
 ==Reference==
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 [[Category: Rna]]
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