1lk2: Difference between revisions

Revision as of 21:16, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1lk2.png

Template:STRUCTURE 1lk2

1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide

Template:ABSTRACT PUBMED 14978103

About this StructureAbout this Structure

1LK2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects., Rudolph MG, Shen LQ, Lamontagne SA, Luz JG, Delaney JR, Ge Q, Cho BK, Palliser D, McKinley CA, Chen J, Wilson IA, Eisen HN, J Immunol. 2004 Mar 1;172(5):2994-3002. PMID:14978103

Page seeded by OCA on Wed Jul 2 21:16:37 2008

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OCA

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-'''1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide'''
+===1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide===
-==Overview==
+<!--
-We identify and consider some characteristics of a peptide antagonist for the Ag-specific receptor on 2C cells (the 2C TCR). The peptide, GNYSFYAL (called GNY), binds to H-2K(b), and a very high-resolution crystal structure of the GNY-K(b) complex at 1.35 A is described. Although the GNY peptide does not bind to L(d), the potency of GNY-K(b) as an antagonist is evident from its ability to specifically inhibit 2C TCR-mediated reactions to an allogenic agonist complex (QLSPFPFDL-L(d)), as well as to a syngeneic agonist complex (SIYRYYGL-K(b)). The crystal structure and the activities of alanine-substituted peptide variants point to the properties of the peptide P4 side chain and the conformation of the Tyr-P6 side chain as the structural determinants of GNYSFYAL antagonist activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_14978103}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14978103 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_14978103}}
 ==About this Structure==
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 [[Category: Class i mhc-peptide complex]]
 [[Category: High resolution]]
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