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| {{STRUCTURE_1l1s| PDB=1l1s | SCENE= }} | | {{STRUCTURE_1l1s| PDB=1l1s | SCENE= }} |
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| '''Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum'''
| | ===Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum=== |
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| ==Overview==
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| As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12021439}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12021439 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12021439}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Psi]] | | [[Category: Psi]] |
| [[Category: Structural genomic]] | | [[Category: Structural genomic]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:26:34 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:30:43 2008'' |