1kmi: Difference between revisions

Revision as of 10:33, 2 July 2008

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File:1kmi.png

Template:STRUCTURE 1kmi

CRYSTAL STRUCTURE OF AN E.COLI CHEMOTAXIS PROTEIN, CHEZCRYSTAL STRUCTURE OF AN E.COLI CHEMOTAXIS PROTEIN, CHEZ

Template:ABSTRACT PUBMED 12080332

About this StructureAbout this Structure

1KMI is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ., Zhao R, Collins EJ, Bourret RB, Silversmith RE, Nat Struct Biol. 2002 Aug;9(8):570-5. PMID:12080332

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-'''CRYSTAL STRUCTURE OF AN E.COLI CHEMOTAXIS PROTEIN, CHEZ'''
+===CRYSTAL STRUCTURE OF AN E.COLI CHEMOTAXIS PROTEIN, CHEZ===
-==Overview==
+<!--
-The protein CheZ, which has the last unknown structure in the Escherichia coli chemotaxis pathway, stimulates the dephosphorylation of the response regulator CheY by an unknown mechanism. Here we report the co-crystal structure of CheZ with CheY, Mg(2+) and the phosphoryl analog, BeF(3)(-). The predominant structural feature of the CheZ dimer is a long four-helix bundle composed of two helices from each monomer. The side chain of Gln 147 of CheZ inserts into the CheY active site and is essential to the dephosphorylation activity of CheZ. Gln 147 may orient a water molecule for nucleophilic attack, similar to the role of the conserved Gln residue in the RAS family of GTPases. Similarities between the CheY[bond] CheZ and Spo0F [bond]Spo0B structures suggest a general mode of interaction for modulation of response regulator phosphorylation chemistry.
+The line below this paragraph, {{ABSTRACT_PUBMED_12080332}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12080332 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_12080332}}
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 [[Category: Zhao, R.]]
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