1kj2: Difference between revisions

Revision as of 10:25, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1kj2.png

Template:STRUCTURE 1kj2

Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule ComplexMurine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex

Template:ABSTRACT PUBMED 11911820

About this StructureAbout this Structure

1KJ2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex., Reiser JB, Gregoire C, Darnault C, Mosser T, Guimezanes A, Schmitt-Verhulst AM, Fontecilla-Camps JC, Mazza G, Malissen B, Housset D, Immunity. 2002 Mar;16(3):345-54. PMID:11911820

Page seeded by OCA on Wed Jul 2 10:25:08 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex'''
+===Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex===
-==Overview==
+<!--
-The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site.
+The line below this paragraph, {{ABSTRACT_PUBMED_11911820}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11911820 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11911820}}
 ==About this Structure==
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 [[Category: T cell receptor]]
 [[Category: Tcr-pmhc complex]]
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