1kil: Difference between revisions

Revision as of 10:23, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1kil.png

Template:STRUCTURE 1kil

Three-dimensional structure of the complexin/SNARE complexThree-dimensional structure of the complexin/SNARE complex

Template:ABSTRACT PUBMED 11832227

About this StructureAbout this Structure

1KIL is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:11832227

Page seeded by OCA on Wed Jul 2 10:23:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Three-dimensional structure of the complexin/SNARE complex'''
+===Three-dimensional structure of the complexin/SNARE complex===
-==Overview==
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-During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca(2+)-evoked neurotransmitter release.
+The line below this paragraph, {{ABSTRACT_PUBMED_11832227}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11832227}}
 ==About this Structure==
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 [[Category: Tomchick, D.]]
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