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OCA

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-[[Image:1kg0.gif|left|200px]]
+{{Seed}}
+[[Image:1kg0.png|left|200px]]
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 {{STRUCTURE_1kg0|  PDB=1kg0  |  SCENE=  }}
-'''Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1'''
+===Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1===
-==Overview==
+<!--
-Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. EBV gp42 belongs to the C-type lectin superfamily, with homology to NK receptors of the immune system. We report the crystal structure of gp42 bound to the human MHC class II molecule HLA-DR1. The gp42 binds HLA-DR1 using a surface site that is distinct from the canonical lectin and NK receptor ligand binding sites. At the canonical ligand binding site, gp42 forms a large hydrophobic groove, which could interact with other ligands necessary for EBV entry, providing a mechanism for coupling MHC recognition and membrane fusion.
+The line below this paragraph, {{ABSTRACT_PUBMED_11864610}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11864610 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11864610}}
 ==About this Structure==
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 [[Category: Mhc]]
 [[Category: Virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:42:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 10:17:32 2008''