1key: Difference between revisions

Revision as of 10:14, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1key.png

Template:STRUCTURE 1key

Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)

Template:ABSTRACT PUBMED 12079346

About this StructureAbout this Structure

1KEY is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein., Pascal JM, Hart PJ, Hecht NB, Robertus JD, J Mol Biol. 2002 Jun 21;319(5):1049-57. PMID:12079346

Page seeded by OCA on Wed Jul 2 10:14:31 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)'''
+===Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)===
-==Overview==
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-The testis/brain-RNA-binding protein (TB-RBP) spatially and temporally controls the expression of specific mRNAs in developing male germ cells and brain cells, and is implicated in DNA recombination and repair events. We report the 2.65 A crystal structure of mouse TB-RBP. The structure is predominantly alpha-helical and exhibits a novel protein fold and mode of assembly. Crystal symmetry and molecular symmetry combine to form an octet of TB-RBP monomers in the shape of an elongated spherical particle with a large cavity at its center. Amino acid residues that affect RNA and DNA binding are located on the interior surface of the assembled particle, and a putative nucleotide-binding domain that controls RNA binding is located at a dimer interface. Other modes of assembly are suggested for TB-RBP based on our structure and recently reported electron microscopic reconstructions of human TB-RBP.
+The line below this paragraph, {{ABSTRACT_PUBMED_12079346}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12079346}}
 ==About this Structure==
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 [[Category: Rna-binding protein]]
 [[Category: Tetramer/octamer assembly]]
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