1kb9: Difference between revisions

Revision as of 10:04, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1kb9.png

Template:STRUCTURE 1kb9

YEAST CYTOCHROME BC1 COMPLEXYEAST CYTOCHROME BC1 COMPLEX

Template:ABSTRACT PUBMED 11726495

About this StructureAbout this Structure

1KB9 is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure., Lange C, Nett JH, Trumpower BL, Hunte C, EMBO J. 2001 Dec 3;20(23):6591-600. PMID:11726495

Page seeded by OCA on Wed Jul 2 10:04:33 2008

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-'''YEAST CYTOCHROME BC1 COMPLEX'''
+===YEAST CYTOCHROME BC1 COMPLEX===
-==Overview==
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-Biochemical data have shown that specific, tightly bound phospholipids are essential for activity of the cytochrome bc1 complex (QCR), an integral membrane protein of the respiratory chain. However, the structure and function of such phospholipids are not yet known. Here we describe five phospholipid molecules and one detergent molecule in the X-ray structure of yeast QCR at 2.3 A resolution. Their individual binding sites suggest specific roles in facilitating structural and functional integrity of the enzyme. Interestingly, a phosphatidylinositol molecule is bound in an unusual interhelical position near the flexible linker region of the Rieske iron-sulfur protein. Two possible proton uptake pathways at the ubiquinone reduction site have been identified: the E/R and the CL/K pathway. Remarkably, cardiolipin is positioned at the entrance to the latter. We propose that cardiolipin ensures structural integrity of the proton-conducting protein environment and takes part directly in proton uptake. Site-directed mutagenesis of ligating residues confirmed the importance of the phosphatidylinositol- and cardiolipin-binding sites.
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 [[Category: Ubiquinone]]
 [[Category: Undecyl-maltopyranoside]]
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