1k5w: Difference between revisions

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-[[Image:1k5w.jpg|left|200px]]
+{{Seed}}
+[[Image:1k5w.png|left|200px]]
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 {{STRUCTURE_1k5w|  PDB=1k5w  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE'''
+===THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE===
-==Overview==
+<!--
-Synaptotagmin 1 probably functions as a Ca2+ sensor in neurotransmitter release via its two C2-domains, but no common Ca2+-dependent activity that could underlie a cooperative action between them has been described. The NMR structure of the C2B-domain now reveals a beta sandwich that exhibits striking similarities and differences with the C2A-domain. Whereas the bottom face of the C2B-domain has two additional alpha helices that may be involved in specialized Ca2+-independent functions, the top face binds two Ca2+ ions and is remarkably similar to the C2A-domain. Consistent with these results, but in contrast to previous studies, we find that the C2B-domain binds phospholipids in a Ca2+-dependent manner similarly to the C2A-domain. These results suggest a novel view of synaptotagmin function whereby the two C2-domains cooperate in a common activity, Ca2+-dependent phospholipid binding, to trigger neurotransmitter release.
+The line below this paragraph, {{ABSTRACT_PUBMED_11754837}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11754837 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11754837}}
 ==About this Structure==
-K5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA].
+K5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA].
 ==Reference==
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 [[Category: Synaptic vesicle exocytosis]]
 [[Category: Synaptotagmin i]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:21:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 09:50:16 2008''