1k2p: Difference between revisions

Revision as of 21:39, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1k2p.png

Template:STRUCTURE 1k2p

Crystal structure of Bruton's tyrosine kinase domainCrystal structure of Bruton's tyrosine kinase domain

Template:ABSTRACT PUBMED 11527964

About this StructureAbout this Structure

1K2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia., Mao C, Zhou M, Uckun FM, J Biol Chem. 2001 Nov 2;276(44):41435-43. Epub 2001 Aug 29. PMID:11527964

Page seeded by OCA on Tue Jul 1 21:38:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of Bruton's tyrosine kinase domain'''
+===Crystal structure of Bruton's tyrosine kinase domain===
-==Overview==
+<!--
-Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided.
+The line below this paragraph, {{ABSTRACT_PUBMED_11527964}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11527964}}
 ==About this Structure==
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 [[Category: Bruton tryosine kinase]]
 [[Category: Kinase domain]]
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