1k2a: Difference between revisions

Revision as of 21:26, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1k2a.png

Template:STRUCTURE 1k2a

Modified Form of Eosinophil-derived NeurotoxinModified Form of Eosinophil-derived Neurotoxin

Template:ABSTRACT PUBMED 11916383

About this StructureAbout this Structure

1K2A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities., Chang C, Newton DL, Rybak SM, Wlodawer A, J Mol Biol. 2002 Mar 15;317(1):119-30. PMID:11916383

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OCA

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-'''Modified Form of Eosinophil-derived Neurotoxin'''
+===Modified Form of Eosinophil-derived Neurotoxin===
-==Overview==
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-The crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A). Two of the extra residues can be placed unambiguously, while the density corresponding to two others is poor. The modified N terminus appears to influence the position of the catalytically important His129, possibly explaining the diminished catalytic activity of this variant. However, (-4)EDN has been shown to be cytotoxic to a Kaposi's sarcoma tumor cell line and other endothelial cell lines. Analysis of the structure and function suggests that the reason for cytotoxicity is most likely due to cellular recognition by the N-terminal extension, since the intrinsic activity of the enzyme is not sufficient for cytotoxicity and the N-terminal extension does not affect the conformation of EDN.
+The line below this paragraph, {{ABSTRACT_PUBMED_11916383}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11916383}}
 ==About this Structure==
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 [[Category: Wlodawer, A.]]
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