1jum: Difference between revisions

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-[[Image:1jum.jpg|left|200px]]
+{{Seed}}
+[[Image:1jum.png|left|200px]]
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 {{STRUCTURE_1jum|  PDB=1jum  |  SCENE=  }}
-'''Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine'''
+===Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine===
-==Overview==
+<!--
-The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse cationic lipophilic drugs. Here, we report the crystal structures of six QacR-drug complexes. Compared to the DNA bound structure, drug binding elicits a coil-to-helix transition that causes induction and creates an expansive multidrug-binding pocket, containing four glutamates and multiple aromatic and polar residues. These structures indicate the presence of separate but linked drug-binding sites within a single protein. This multisite drug-binding mechanism is consonant with studies on multidrug resistance transporters.
+The line below this paragraph, {{ABSTRACT_PUBMED_11739955}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11739955 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11739955}}
 ==About this Structure==
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 [[Category: Qacr]]
 [[Category: S. aureus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:56:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:54:52 2008''