1jr4: Difference between revisions
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{{STRUCTURE_1jr4| PDB=1jr4 | SCENE= }} | {{STRUCTURE_1jr4| PDB=1jr4 | SCENE= }} | ||
===CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX=== | |||
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[[Category: Neurotransmitter degradation]] | [[Category: Neurotransmitter degradation]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 20:40, 1 July 2008
CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEXCATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX
About this StructureAbout this Structure
1JR4 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. , Lerner C, Ruf A, Gramlich V, Masjost B, Zurcher G, Jakob-Roetne R, Borroni E, Diederich F, Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. PMID:12404486
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