1jq2: Difference between revisions

Revision as of 20:37, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1jq2.png

Template:STRUCTURE 1jq2

POTASSIUM CHANNEL (KCSA) OPEN GATE MODELPOTASSIUM CHANNEL (KCSA) OPEN GATE MODEL

Template:ABSTRACT PUBMED 11573095

About this StructureAbout this Structure

1JQ2 is a Single protein structure of sequence from Streptomyces lividans. Full experimental information is available from OCA.

ReferenceReference

Structure of the KcsA channel intracellular gate in the open state., Liu YS, Sompornpisut P, Perozo E, Nat Struct Biol. 2001 Oct;8(10):883-7. PMID:11573095

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-'''POTASSIUM CHANNEL (KCSA) OPEN GATE MODEL'''
+===POTASSIUM CHANNEL (KCSA) OPEN GATE MODEL===
-==Overview==
+<!--
-Ion channels catalyze the selective transfer of ions across the membrane in response to a variety of stimuli. These channels gate by controlling the access of ions to a centrally located water-filled pore. The crystal structure of the Streptomyces lividans potassium channel (KcsA) has allowed a molecular exploration of this mechanism. Electron paramagnetic resonance (EPR) studies have uncovered significant conformational changes at the intracellular end of the second transmembrane helix (TM2) upon gating. We have used site-directed spin labeling (SDSL) and EPR spectroscopy in an attempt to quantify the structural rearrangements of the KcsA TM2 bundle underlying the transition from the closed to the open state. Under conditions favoring the closed and open conformations, 10 intersubunit distances were obtained across TM2 segments from tandem dimer constructs. Analysis of these data points to a mechanism in which each TM2 helix tilts away from the permeation pathway, towards the membrane plane, and rotates about its helical axis, supporting a scissoring-type motion with a pivot point near residues 107-108. These movements are accompanied by a large increase in the diameter of the vestibule below the central water-filled cavity.
+The line below this paragraph, {{ABSTRACT_PUBMED_11573095}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11573095 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11573095}}
 ==About this Structure==
-JQ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQ2 OCA].
+JQ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQ2 OCA].
 ==Reference==
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 [[Category: Open state]]
 [[Category: Potassium channel]]
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