1jlh: Difference between revisions

Revision as of 20:25, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1jlh.png

Template:STRUCTURE 1jlh

Human Glucose-6-phosphate IsomeraseHuman Glucose-6-phosphate Isomerase

Template:ABSTRACT PUBMED 12573240

About this StructureAbout this Structure

1JLH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps., Cordeiro AT, Godoi PH, Silva CH, Garratt RC, Oliva G, Thiemann OH, Biochim Biophys Acta. 2003 Feb 21;1645(2):117-22. PMID:12573240

Page seeded by OCA on Tue Jul 1 20:25:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Human Glucose-6-phosphate Isomerase'''
+===Human Glucose-6-phosphate Isomerase===
-==Overview==
+<!--
-The second enzyme in the glycolytic pathway, phosphoglucose isomerase (PGI), catalyses an intracellular aldose-ketose isomerization. Here we describe the human recombinant PGI structure (hPGI) solved in the absence of active site ligands. Crystals isomorphous to those previously reported were used to collect a 94% complete data set to a limiting resolution of 2.1 A. From the comparison between the free active site hPGI structure and the available human and rabbit PGI (rPGI) structures, a mechanism for protein initial catalytic steps is proposed. Binding of the phosphate moiety of the substrate to two distinct elements of the active site is responsible for driving a series of structural changes resulting in the polarisation of the active site histidine, priming it for the initial ring-opening step of catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_12573240}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12573240 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_12573240}}
 ==About this Structure==
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 [[Category: Glyconeogenesis]]
 [[Category: Isomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:22:11 2008''
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