1jld: Difference between revisions

Revision as of 20:25, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1jld.png

Template:STRUCTURE 1jld

POTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTEREPOTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTERE

Template:ABSTRACT PUBMED 9216835

About this StructureAbout this Structure

1JLD is a Single protein structure of sequence from Human immunodeficiency virus 2. Full crystallographic information is available from OCA.

ReferenceReference

Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere., Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L, J Med Chem. 1997 Jul 4;40(14):2164-76. PMID:9216835

Page seeded by OCA on Tue Jul 1 20:25:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1jld.gif|left|200px]]
+{{Seed}}
+[[Image:1jld.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1jld|  PDB=1jld  |  SCENE=  }}
-'''POTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTERE'''
+===POTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTERE===
-==Overview==
+<!--
-A series of HIV protease inhibitors containing a novel (hydroxyethyl)amidosuccinoyl core has been synthesized. These peptidomimetic structures inhibit viral protease activity at low nanomolar concentrations (IC50 &lt; 10 nM for HIV-1 protease). The inhibition constant (Ki) for inhibitor 19 was determined to be 7.5 pM against HIV-1 and 1.2 nM against HIV-2 proteases, respectively. Several compounds (19-24) inhibited HIV-1 replication in cell culture assays with 50% effective concentrations (EC50) = 3.7-35 nM. This series of inhibitors was found to exhibit poor bioavailability (&lt; 10%) in the rat, following oral administration. The synthesis and biological properties of these compounds are discussed. In addition, an X-ray structure of one of these inhibitors (23) in complex with HIV-2 protease provides insight into the binding mode of this novel class of HIV protease inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_9216835}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9216835 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9216835}}
 ==About this Structure==
@@ Line 26: / Line 30: @@
 [[Category: Hiv-2 protease]]
 [[Category: Polyprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:21:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:25:28 2008''