|
|
| Line 1: |
Line 1: |
| [[Image:1jf1.gif|left|200px]] | | {{Seed}} |
| | [[Image:1jf1.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1jf1| PDB=1jf1 | SCENE= }} | | {{STRUCTURE_1jf1| PDB=1jf1 | SCENE= }} |
|
| |
|
| '''Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A'''
| | ===Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| We have determined high-resolution crystal structures of the complexes of HLA-A2 molecules with two modified immunodominant peptides from the melanoma tumor-associated protein Melan-A/Melanoma Ag recognized by T cells-1. The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), are modified in the second residue to increase their affinity for HLA-A2. The modified decamer is more immunogenic than the natural peptide and a candidate for peptide-based melanoma immunotherapy. The crystal structures at 1.8 and 2.15 A resolution define the differences in binding modes of the modified peptides, including different clusters of water molecules that appear to stabilize the peptide-HLA interaction. The structures suggest both how the wild-type peptides would bind and how three categories of cytotoxic T lymphocytes with differing fine specificity might recognize the two peptides.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11544315}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11544315 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_11544315}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 36: |
Line 40: |
| [[Category: Tumor immunity]] | | [[Category: Tumor immunity]] |
| [[Category: Vaccination]] | | [[Category: Vaccination]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:08:44 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:08:45 2008'' |