1jd6: Difference between revisions

Revision as of 20:03, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1jd6.png

Template:STRUCTURE 1jd6

Crystal Structure of DIAP1-BIR2/Hid ComplexCrystal Structure of DIAP1-BIR2/Hid Complex

Template:ABSTRACT PUBMED 11511363

About this StructureAbout this Structure

1JD6 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides., Wu JW, Cocina AE, Chai J, Hay BA, Shi Y, Mol Cell. 2001 Jul;8(1):95-104. PMID:11511363

Page seeded by OCA on Tue Jul 1 20:03:29 2008

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OCA

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-[[Image:1jd6.gif|left|200px]]
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-'''Crystal Structure of DIAP1-BIR2/Hid Complex'''
+===Crystal Structure of DIAP1-BIR2/Hid Complex===
-==Overview==
+<!--
-The inhibitor of apoptosis protein DIAP1 suppresses apoptosis in Drosophila, with the second BIR domain (BIR2) playing an important role. Three proteins, Hid, Grim, and Reaper, promote apoptosis, in part by binding to DIAP1 through their conserved N-terminal sequences. The crystal structures of DIAP1-BIR2 by itself and in complex with the N-terminal peptides from Hid and Grim reveal that these peptides bind a surface groove on DIAP1, with the first four amino acids mimicking the binding of the Smac tetrapeptide to XIAP. The next 3 residues also contribute to binding through hydrophobic interactions. Interestingly, peptide binding induces the formation of an additional alpha helix in DIAP1. Our study reveals the structural conservation and diversity necessary for the binding of IAPs by the Drosophila Hid/Grim/Reaper and the mammalian Smac proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_11511363}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11511363 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11511363}}
 ==About this Structure==
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 [[Category: Hid]]
 [[Category: Iap]]
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