1jbb: Difference between revisions

Revision as of 19:57, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1jbb.png

Template:STRUCTURE 1jbb

Ubiquitin Conjugating Enzyme, Ubc13Ubiquitin Conjugating Enzyme, Ubc13

Template:ABSTRACT PUBMED 11440714

About this StructureAbout this Structure

1JBB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer., VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C, Cell. 2001 Jun 15;105(6):711-20. PMID:11440714

Page seeded by OCA on Tue Jul 1 19:57:43 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Ubiquitin Conjugating Enzyme, Ubc13'''
+===Ubiquitin Conjugating Enzyme, Ubc13===
-==Overview==
+<!--
-While the signaling properties of ubiquitin depend on the topology of polyubiquitin chains, little is known concerning the molecular basis of specificity in chain assembly and recognition. UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and I kappa B alpha kinase activation. The crystal structure of the Mms2/Ubc13 heterodimer shows the active site of Ubc13 at the intersection of two channels that are potential binding sites for the two substrate ubiquitins. Mutations that destabilize the heterodimer interface confer a marked UV sensitivity, providing direct evidence that the intact heterodimer is necessary for DNA repair. Selective mutations in the channels suggest a molecular model for specificity in the assembly of Lys63-linked polyubiquitin signals.
+The line below this paragraph, {{ABSTRACT_PUBMED_11440714}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11440714 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11440714}}
 ==About this Structure==
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 [[Category: Ubiquitin]]
 [[Category: Ubiquitin-conjugating enzyme]]
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