|
|
| Line 1: |
Line 1: |
| [[Image:1j1d.gif|left|200px]] | | {{Seed}} |
| | [[Image:1j1d.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1j1d| PDB=1j1d | SCENE= }} | | {{STRUCTURE_1j1d| PDB=1j1d | SCENE= }} |
|
| |
|
| '''Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form'''
| | ===Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Troponin is essential in Ca(2+) regulation of skeletal and cardiac muscle contraction. It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament. Here we present crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardiac troponin in the Ca(2+)-saturated form. Analysis of the four-molecule structures reveals that the core domain is further divided into structurally distinct subdomains that are connected by flexible linkers, making the entire molecule highly flexible. The alpha-helical coiled-coil formed between TnT and TnI is integrated in a rigid and asymmetric structure (about 80 angstrom long), the IT arm, which bridges putative tropomyosin-anchoring regions. The structures of the troponin ternary complex imply that Ca(2+) binding to the regulatory site of TnC removes the carboxy-terminal portion of TnI from actin, thereby altering the mobility and/or flexibility of troponin and tropomyosin on the actin filament.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12840750}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12840750 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_12840750}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 31: |
Line 35: |
| [[Category: Muscle regulation]] | | [[Category: Muscle regulation]] |
| [[Category: Thin filament]] | | [[Category: Thin filament]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:40:56 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:21:03 2008'' |