1is3: Difference between revisions

Revision as of 13:54, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1is3.png

Template:STRUCTURE 1is3

LACTOSE AND MES-LIGANDED CONGERIN IILACTOSE AND MES-LIGANDED CONGERIN II

Template:ABSTRACT PUBMED 12206768

About this StructureAbout this Structure

1IS3 is a Single protein structure of sequence from Conger myriaster. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768

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OCA

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-'''LACTOSE AND MES-LIGANDED CONGERIN II'''
+===LACTOSE AND MES-LIGANDED CONGERIN II===
-==Overview==
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-The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
+The line below this paragraph, {{ABSTRACT_PUBMED_12206768}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Yamane, T.]]
 [[Category: Complex with lactose and me]]
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