1iru: Difference between revisions

Revision as of 13:53, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1iru.png

Template:STRUCTURE 1iru

Crystal Structure of the mammalian 20S proteasome at 2.75 A resolutionCrystal Structure of the mammalian 20S proteasome at 2.75 A resolution

Template:ABSTRACT PUBMED 12015144

About this StructureAbout this Structure

1IRU is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the mammalian 20S proteasome at 2.75 A resolution., Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T, Structure. 2002 May;10(5):609-18. PMID:12015144

Page seeded by OCA on Tue Jul 1 13:53:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1iru.gif|left|200px]]
+{{Seed}}
+[[Image:1iru.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1iru|  PDB=1iru  |  SCENE=  }}
-'''Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution'''
+===Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution===
-==Overview==
+<!--
-The 20S proteasome is the catalytic portion of the 26S proteasome. Constitutively expressed mammalian 20S proteasomes have three active subunits, beta 1, beta 2, and beta 5, which are replaced in the immunoproteasome by interferon-gamma-inducible subunits beta 1i, beta 2i, and beta 5i, respectively. Here we determined the crystal structure of the bovine 20S proteasome at 2.75 A resolution. The structures of alpha 2, beta 1, beta 5, beta 6, and beta 7 subunits of the bovine enzyme were different from the yeast enzyme but enabled the bovine proteasome to accommodate either the constitutive or the inducible subunits. A novel N-terminal nucleophile hydrolase activity was proposed for the beta 7 subunit. We also determined the site of the nuclear localization signals in the molecule. A model of the immunoproteasome was predicted from this constitutive structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_12015144}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12015144 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12015144}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Proteolysis]]
 [[Category: Ubiquitin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:20:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 13:53:23 2008''