|
|
| Line 1: |
Line 1: |
| [[Image:1iqd.jpg|left|200px]] | | {{Seed}} |
| | [[Image:1iqd.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1iqd| PDB=1iqd | SCENE= }} | | {{STRUCTURE_1iqd| PDB=1iqd | SCENE= }} |
|
| |
|
| '''Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.'''
| | ===Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| The development of an immune response to infused factor VIII is a complication affecting many patients with hemophilia A. Inhibitor antibodies bind to antigenic determinants on the factor VIII molecule and block its procoagulant activity. A patient-derived inhibitory immunoglobulin G4kappa antibody (BO2C11) produced by an immortalized memory B-lymphocyte cell line interferes with the binding of factor VIII to phospholipid surfaces and to von Willebrand factor. The structure of a Fab fragment derived from this antibody complexed with the factor VIII C2 domain was determined at 2.0 A resolution. The Fab interacts with solvent-exposed basic and hydrophobic side chains that form a membrane-association surface of factor VIII. This atomic resolution structure suggests a variety of amino acid substitutions in the C2 domain of factor VIII that might prevent the binding of anti-C2 inhibitor antibodies without significantly compromising the procoagulant functions of factor VIII. | | The line below this paragraph, {{ABSTRACT_PUBMED_11418455}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11418455 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_11418455}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 33: |
Line 37: |
| [[Category: Factor viii]] | | [[Category: Factor viii]] |
| [[Category: Inhibitor]] | | [[Category: Inhibitor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:16:52 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:48:29 2008'' |