|
|
| Line 1: |
Line 1: |
| [[Image:1iob.gif|left|200px]] | | {{Seed}} |
| | [[Image:1iob.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1iob| PDB=1iob | SCENE= }} | | {{STRUCTURE_1iob| PDB=1iob | SCENE= }} |
|
| |
|
| '''INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT'''
| | ===INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Joint refinement of macromolecules against crystallographic and nuclear magnetic resonance (NMR) observations is presented as a way of combining experimental information from the two methods. The model of interleukin-1 beta derived by the joint x-ray and NMR refinement is shown to be consistent with the experimental observations of both methods and to have crystallographic R value and geometrical parameters that are of the same quality as or better than those of models obtained by conventional crystallographic studies. The few NMR observations that are violated by the model serve as an indicator for genuine differences between the crystal and solution structures. The joint x-ray-NMR refinement can resolve structural ambiguities encountered in studies of multidomain proteins, in which low- to medium-resolution diffraction data can be complemented by higher resolution NMR data obtained for the individual domains.
| | The line below this paragraph, {{ABSTRACT_PUBMED_1502561}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 1502561 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_1502561}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 29: |
Line 33: |
| [[Category: Mitogen]] | | [[Category: Mitogen]] |
| [[Category: Pyrogen]] | | [[Category: Pyrogen]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:12:58 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:40:35 2008'' |