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| {{STRUCTURE_1inq| PDB=1inq | SCENE= }} | | {{STRUCTURE_1inq| PDB=1inq | SCENE= }} |
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| '''Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db'''
| | ===Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db=== |
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| ==Overview==
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| The mouse H13 minor histocompatibility (H) Ag, originally detected as a barrier to allograft transplants, is remarkable in that rejection is a consequence of an extremely subtle interchange, P4(Val/Ile), in a nonamer H2-D(b)-bound peptide. Moreover, H13 peptides lack the canonical P5(Asn) central anchor residue normally considered important for forming a peptide/MHC complex. To understand how these noncanonical peptide pMHC complexes form physiologically active TCR ligands, crystal structures of allelic H13 pD(b) complexes and a P5(Asn) anchored pD(b) analog were solved to high resolution. The structures show that the basis of TCRs to distinguish self from nonself H13 peptides is their ability to distinguish a single solvent-exposed methyl group. In addition, the structures demonstrate that there is no need for H13 peptides to derive any stabilization from interactions within the central C pocket to generate fully functional pMHC complexes. These results provide a structural explanation for a classical non-MHC-encoded H Ag, and they call into question the requirement for contact between anchor residues and the major MHC binding pockets in vaccine design. | | The line below this paragraph, {{ABSTRACT_PUBMED_11751972}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11751972 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11751972}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Mhc complex]] | | [[Category: Mhc complex]] |
| [[Category: Minor histocompatibility antigen]] | | [[Category: Minor histocompatibility antigen]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:11:50 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:37:35 2008'' |