1ij0: Difference between revisions

Revision as of 12:18, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ij0.png

Template:STRUCTURE 1ij0

Coiled Coil Trimer GCN4-pVLS Ser at Buried D PositionCoiled Coil Trimer GCN4-pVLS Ser at Buried D Position

Template:ABSTRACT PUBMED 11371197

About this StructureAbout this Structure

1IJ0 is a Single protein structure. Full crystallographic information is available from OCA.

ReferenceReference

Buried polar residues in coiled-coil interfaces., Akey DL, Malashkevich VN, Kim PS, Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197

Page seeded by OCA on Tue Jul 1 12:18:17 2008

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OCA

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-'''Coiled Coil Trimer GCN4-pVLS Ser at Buried D Position'''
+===Coiled Coil Trimer GCN4-pVLS Ser at Buried D Position===
-==Overview==
+<!--
-Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.
+The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11371197}}
 ==About this Structure==
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 [[Category: Malashkevich, V N.]]
 [[Category: Coiled coil trimer]]
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