1idz: Difference between revisions

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[[Image:1idz.jpg|left|200px]]
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{{STRUCTURE_1idz|  PDB=1idz  |  SCENE=  }}  
{{STRUCTURE_1idz|  PDB=1idz  |  SCENE=  }}  


'''STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES'''
===STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES===




==Overview==
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A small globular protein, the third repeat of the c-Myb DNA-binding domain, which is composed of 54 amino acid residues, was engineered so as to understand the structural uniqueness of native proteins. This small protein has three alpha-helices that form a helix-turn-helix structure, which is maintained by the hydrophobic core with three Ile residues. One of the mutant proteins, with two of the buried Ile (Ile-155 and Ile-181) substituted with Leu residues, showed multiple conformations, as monitored by heteronuclear magnetic resonance spectroscopy for 13C- and 15N-labeled proteins. The increase in the side-chain conformational entropy, caused by changing the Ile to a Leu residue on an alpha-helix, could engender the lack of structural uniqueness. In native proteins, the conformations of not only the beta-branched side chains, but also those of the neighboring bulky side chains, can be greatly restricted, depending upon the local backbone structure.
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{{ABSTRACT_PUBMED_8942977}}


==About this Structure==
==About this Structure==
1IDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDZ OCA].  
1IDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDZ OCA].  


==Reference==
==Reference==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Protooncogene product]]
[[Category: Protooncogene product]]
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