1ido: Difference between revisions

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OCA

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-[[Image:1ido.gif|left|200px]]
+{{Seed}}
+[[Image:1ido.png|left|200px]]
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 {{STRUCTURE_1ido|  PDB=1ido  |  SCENE=  }}
-'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''
+===I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND===
-==Overview==
+<!--
-We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.
+The line below this paragraph, {{ABSTRACT_PUBMED_7867070}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7867070 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7867070}}
 ==About this Structure==
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 [[Category: Glycoprotein]]
 [[Category: Integrin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:53:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:48:43 2008''