1iap: Difference between revisions

Revision as of 10:40, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1iap.png

Template:STRUCTURE 1iap

CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAINCRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN

Template:ABSTRACT PUBMED 11524686

About this StructureAbout this Structure

1IAP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:11524686

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-'''CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN'''
+===CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN===
-==Overview==
+<!--
-p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.
+The line below this paragraph, {{ABSTRACT_PUBMED_11524686}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11524686 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11524686}}
 ==About this Structure==
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