1ia8: Difference between revisions

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-[[Image:1ia8.gif|left|200px]]
+{{Seed}}
+[[Image:1ia8.png|left|200px]]
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 {{STRUCTURE_1ia8|  PDB=1ia8  |  SCENE=  }}
-'''THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1'''
+===THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1===
-==Overview==
+<!--
-The checkpoint kinase Chk1 is an important mediator of cell cycle arrest following DNA damage. The 1.7 A resolution crystal structures of the human Chk1 kinase domain and its binary complex with an ATP analog has revealed an identical open kinase conformation. The secondary structure and side chain interactions stabilize the activation loop of Chk1 and enable kinase activity without phosphorylation of the catalytic domain. Molecular modeling of the interaction of a Cdc25C peptide with Chk1 has uncovered several conserved residues that are important for substrate selectivity. In addition, we found that the less conserved C-terminal region negatively impacts Chk1 kinase activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_10761933}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10761933 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10761933}}
 ==About this Structure==
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 [[Category: Tempczyk-Russell, A.]]
 [[Category: Protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:45:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:39:27 2008''