1h4u: Difference between revisions

Revision as of 06:37, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1h4u.png

Template:STRUCTURE 1h4u

DOMAIN G2 OF MOUSE NIDOGEN-1DOMAIN G2 OF MOUSE NIDOGEN-1

Template:ABSTRACT PUBMED 11427896

About this StructureAbout this Structure

1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896

Page seeded by OCA on Tue Jul 1 06:37:35 2008

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OCA

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-[[Image:1h4u.gif|left|200px]]
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-'''DOMAIN G2 OF MOUSE NIDOGEN-1'''
+===DOMAIN G2 OF MOUSE NIDOGEN-1===
-==Overview==
+<!--
-Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_11427896}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11427896 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11427896}}
 ==About this Structure==
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 [[Category: Timpl, R.]]
 [[Category: Extracellular matrix protein]]
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