1ga3: Difference between revisions

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[[Image:1ga3.jpg|left|200px]]
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[[Image:1ga3.png|left|200px]]


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{{STRUCTURE_1ga3|  PDB=1ga3  |  SCENE=  }}  
{{STRUCTURE_1ga3|  PDB=1ga3  |  SCENE=  }}  


'''NMR STRUCTURE OF INTERLEUKIN-13'''
===NMR STRUCTURE OF INTERLEUKIN-13===




==Overview==
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The complex and interrelated function of the interleukin cytokines relies on a range of pro-inflammatory and anti-inflammatory immune responses mediated by an array of receptors, and there is considerable cross-reactivity for related cytokines. Recent findings continue to elucidate the expression patterns of interleukin receptors associated with a range of diseases, including cancer. We report here the first experimentally determined high-resolution structure of human interleukin-13 (IL-13). The experimental structure is significantly different from an earlier homology model, which could have led to improper estimation of receptor interaction surfaces and design of mutational experiments. Similarities between the presented IL-13 structure and the homologous interleukin-4 (IL-4) are discussed. Additionally, mutation data for IL-4 and IL-13 are analyzed and combined with a detailed structural analysis of the IL-4/IL4Ralpha interface that leads us to postulate interactions at the IL-13/receptor interface. The structural comparison is used to interpret the different affinities for various receptors and establishes the basis for further mutational experiments and antagonist design.
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{{ABSTRACT_PUBMED_11419949}}


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1GA3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GA3 OCA].  
1GA3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GA3 OCA].  


==Reference==
==Reference==
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[[Category: Horita, D A.]]
[[Category: Horita, D A.]]
[[Category: Interleukin-13,il-13,il13,cytokine]]
[[Category: Interleukin-13,il-13,il13,cytokine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:20:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:58:34 2008''

Revision as of 04:58, 1 July 2008

File:1ga3.png

Template:STRUCTURE 1ga3

NMR STRUCTURE OF INTERLEUKIN-13NMR STRUCTURE OF INTERLEUKIN-13

Template:ABSTRACT PUBMED 11419949

DiseaseDisease

Known disease associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]

About this StructureAbout this Structure

1GA3 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Solution structure of interleukin-13 and insights into receptor engagement., Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA, J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:11419949

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