1g37: Difference between revisions

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[[Image:1g37.gif|left|200px]]
{{Seed}}
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{{STRUCTURE_1g37|  PDB=1g37  |  SCENE=  }}  
{{STRUCTURE_1g37|  PDB=1g37  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE'''
===CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE===




==Overview==
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Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.
The line below this paragraph, {{ABSTRACT_PUBMED_11212093}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11212093}}


==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Thrombin]]
[[Category: Thrombin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:04:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:20:43 2008''

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