1fzz: Difference between revisions

Revision as of 04:11, 1 July 2008

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File:1fzz.png

Template:STRUCTURE 1fzz

THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.

Template:ABSTRACT PUBMED 11310599

About this StructureAbout this Structure

1FZZ is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase., Odagaki Y, Ohmoto K, Matsuoka S, Hamanaka N, Nakai H, Toda M, Katsuya Y, Bioorg Med Chem. 2001 Mar;9(3):647-51. PMID:11310599

Page seeded by OCA on Tue Jul 1 04:11:41 2008

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OCA

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-[[Image:1fzz.gif|left|200px]]
+{{Seed}}
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-'''THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.'''
+===THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.===
-==Overview==
+<!--
-The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1-(methylethyl)-2-oxoethy l]-2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-ly)acetamide (ONO-6818, 1) complexed to porcine pancreatic elastase (PPE) has been determined at 1.86 A resolution. Analytical results provided evidence of a 1:1 complex in which the electrophilic ketone of 1 covalently bound to O gamma of Ser195 at the active site of PPE. The role of the unique electron-withdrawing ketone of 1 has been elucidated.
+The line below this paragraph, {{ABSTRACT_PUBMED_11310599}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11310599 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11310599}}
 ==About this Structure==
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 [[Category: Toda, M.]]
 [[Category: Enzyme-inhibitor complex]]
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