1fza: Difference between revisions

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{{STRUCTURE_1fza|  PDB=1fza  |  SCENE=  }}  
{{STRUCTURE_1fza|  PDB=1fza  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D'''
===CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D===




==Overview==
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In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.
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{{ABSTRACT_PUBMED_9333233}}


==About this Structure==
==About this Structure==
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[[Category: Plasma]]
[[Category: Plasma]]
[[Category: Platelet]]
[[Category: Platelet]]
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Revision as of 04:09, 1 July 2008

File:1fza.png

Template:STRUCTURE 1fza

CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT DCRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D

Template:ABSTRACT PUBMED 9333233

About this StructureAbout this Structure

1FZA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin., Spraggon G, Everse SJ, Doolittle RF, Nature. 1997 Oct 2;389(6650):455-62. PMID:9333233

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