1fyn: Difference between revisions

Revision as of 04:08, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1fyn.png

Template:STRUCTURE 1fyn

PHOSPHOTRANSFERASEPHOSPHOTRANSFERASE

Template:ABSTRACT PUBMED 7664083

About this StructureAbout this Structure

1FYN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides., Musacchio A, Saraste M, Wilmanns M, Nat Struct Biol. 1994 Aug;1(8):546-51. PMID:7664083

Page seeded by OCA on Tue Jul 1 04:08:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1fyn.gif|left|200px]]
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 {{STRUCTURE_1fyn|  PDB=1fyn  |  SCENE=  }}
-'''PHOSPHOTRANSFERASE'''
+===PHOSPHOTRANSFERASE===
-==Overview==
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-Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.
+The line below this paragraph, {{ABSTRACT_PUBMED_7664083}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7664083 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7664083}}
 ==About this Structure==
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 [[Category: Transferase]]
 [[Category: Tyrosine-protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:54:47 2008''
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