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| [[Image:1fpt.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1fpt| PDB=1fpt | SCENE= }} | | {{STRUCTURE_1fpt| PDB=1fpt | SCENE= }} |
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| '''THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE'''
| | ===THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE=== |
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| ==Overview==
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| The crystal structure of the complex between the Fab fragment of C3, a neutralizing antibody for poliovirus, and a peptide corresponding to the viral epitope has been determined at 3.0 A resolution. Although this antibody was originally raised to heat inactivated (noninfectious) virus particles, it strongly neutralizes the Mahoney strain of type 1 poliovirus. Eleven peptide residues are well-defined in the electron-density map and form two type I beta-turns in series. At the carboxyl end, the peptide is bound snugly in the antibody-combining site and adopts a conformation that differs significantly from the structure of the corresponding residues in the virus. Structural comparisons between the peptide in the complex and the viral epitope suggests that on binding to infectious virions, this antibody may induce structural changes important for neutralization. | | The line below this paragraph, {{ABSTRACT_PUBMED_7539711}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 7539711 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_7539711}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Hogle, J M.]] | | [[Category: Hogle, J M.]] |
| [[Category: Wien, M W.]] | | [[Category: Wien, M W.]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:14 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:45:13 2008'' |