1fpr: Difference between revisions

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-[[Image:1fpr.jpg|left|200px]]
+{{Seed}}
+[[Image:1fpr.png|left|200px]]
 <!--
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 {{STRUCTURE_1fpr|  PDB=1fpr  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.'''
+===CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.===
-==Overview==
+<!--
-The substrate specificity of the catalytic domain of SHP-1, an important regulator in the proliferation and development of hematopoietic cells, is critical for understanding the physiological functions of SHP-1. Here we report the crystal structures of the catalytic domain of SHP-1 complexed with two peptide substrates derived from SIRPalpha, a member of the signal-regulatory proteins. We show that the variable beta5-loop-beta6 motif confers SHP-1 substrate specificity at the P-4 and further N-terminal subpockets. We also observe a novel residue shift at P-2, the highly conserved subpocket in protein- tyrosine phosphatases. Our observations provide new insight into the substrate specificity of SHP-1.
+The line below this paragraph, {{ABSTRACT_PUBMED_10660565}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10660565 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10660565}}
 ==About this Structure==
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 [[Category: Residue shift]]
 [[Category: Substrate specificity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:37:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:45:03 2008''