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| [[Image:1fos.gif|left|200px]] | | {{Seed}} |
| | [[Image:1fos.png|left|200px]] |
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| {{STRUCTURE_1fos| PDB=1fos | SCENE= }} | | {{STRUCTURE_1fos| PDB=1fos | SCENE= }} |
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| '''TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES'''
| | ===TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES=== |
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| ==Overview==
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| The Fos and Jun families of eukaryotic transcription factors heterodimerize to form complexes capable of binding 5'-TGAGTCA-3' DNA elements. We have determined the X-ray crystal structure of a heterodimer of the bZIP regions of c-Fos and c-Jun bound to DNA. Both subunits form continuous alpha-helices. The carboxy-terminal regions form an asymmetric coiled-coil, and the amino-terminal regions make base-specific contacts with DNA in the major groove. Comparison of the two crystallographically distinct protein-DNA complexes show that the coiled-coil is flexibly joined to the basic regions and that the Fos-Jun heterodimer does not recognize the asymmetric 5'-TGAGTCA-3' recognition element in a unique orientation. There is an extensive network of electrostatic interactions between subunits within the coiled-coil, consistent with proposals that these interactions determine preferential formation of the heterodimer over either of the homodimers. | | The line below this paragraph, {{ABSTRACT_PUBMED_7816143}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 7816143 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_7816143}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Dna-binding protein]] | | [[Category: Dna-binding protein]] |
| [[Category: Heterodimer]] | | [[Category: Heterodimer]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:35:14 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:41:59 2008'' |