1flj: Difference between revisions

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-[[Image:1flj.jpg|left|200px]]
+{{Seed}}
+[[Image:1flj.png|left|200px]]
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 {{STRUCTURE_1flj|  PDB=1flj  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III'''
+===CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III===
-==Overview==
+<!--
-S-Glutathiolation of carbonic anhydrase III (CAIII) occurs rapidly in hepatocytes under oxidative stress. The crystal structure of the S-glutathiolated CAIII from rat liver reveals covalent adducts on cysteines 183 and 188. Electrostatic charge and steric contacts at each modification site inversely correlate with the relative rates of reactivity of these cysteines toward glutathione (GSH). Diffuse electron density associated with the GSH adducts suggests a lack of preferred bonding interactions between CAIII and the glutathionyl moieties. Hence, the GSH adducts are available for binding by a protein capable of reducing this mixed disulfide. These properties are consistent with the participation of CAIII in the protection/recovery from the damaging effects of oxidative agents.
+The line below this paragraph, {{ABSTRACT_PUBMED_11024467}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11024467 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11024467}}
 ==About this Structure==
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 [[Category: S-glutathiolated]]
 [[Category: S-glutathionylated]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:28:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:26:41 2008''