1fju: Difference between revisions

Revision as of 03:22, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1fju.png

Template:STRUCTURE 1fju

THERMOLYSIN (80% ACETONITRILE SOAKED CRYSTALS)THERMOLYSIN (80% ACETONITRILE SOAKED CRYSTALS)

Template:ABSTRACT PUBMED 11287678

About this StructureAbout this Structure

1FJU is a Single protein structure of sequence from Bacillus thermoproteolyticus. Full crystallographic information is available from OCA.

ReferenceReference

Experimental and computational mapping of the binding surface of a crystalline protein., English AC, Groom CR, Hubbard RE, Protein Eng. 2001 Jan;14(1):47-59. PMID:11287678

Page seeded by OCA on Tue Jul 1 03:22:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1fju.jpg|left|200px]]
+{{Seed}}
+[[Image:1fju.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1fju|  PDB=1fju  |  SCENE=  }}
-'''THERMOLYSIN (80% ACETONITRILE SOAKED CRYSTALS)'''
+===THERMOLYSIN (80% ACETONITRILE SOAKED CRYSTALS)===
-==Overview==
+<!--
-Multiple Solvent Crystal Structures (MSCS) is a crystallographic technique to identify energetically favorable positions and orientations of small organic molecules on the surface of proteins. We determined the high-resolution crystal structures of thermolysin (TLN), generated from crystals soaked in 50--70% acetone, 50--80% acetonitrile and 50 mM phenol. The structures of the protein in the aqueous-organic mixtures are essentially the same as the native enzyme and a number of solvent interaction sites were identified. The distribution of probe molecules shows clusters in the main specificity pocket of the active site and a buried subsite. Within the active site, we compared the experimentally determined solvent positions with predictions from two computational functional group mapping techniques, GRID and Multiple Copy Simultaneous Search (MCSS). The experimentally determined small molecule positions are consistent with the structures of known protein--ligand complexes of TLN.
+The line below this paragraph, {{ABSTRACT_PUBMED_11287678}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11287678 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11287678}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Metalloproteinase]]
 [[Category: Organic solvent]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:24:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:22:46 2008''