1f8c: Difference between revisions

Revision as of 02:51, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1f8c.png

Template:STRUCTURE 1f8c

NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACIDNATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID

Template:ABSTRACT PUBMED 11274459

About this StructureAbout this Structure

1F8C is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

ReferenceReference

Analysis of inhibitor binding in influenza virus neuraminidase., Smith BJ, Colman PM, Von Itzstein M, Danylec B, Varghese JN, Protein Sci. 2001 Apr;10(4):689-96. PMID:11274459

Page seeded by OCA on Tue Jul 1 02:51:34 2008

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OCA

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-[[Image:1f8c.gif|left|200px]]
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 {{STRUCTURE_1f8c|  PDB=1f8c  |  SCENE=  }}
-'''NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID'''
+===NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID===
-==Overview==
+<!--
-,3-didehydro-2-deoxy-N:-acetylneuraminic acid (DANA) is a transition state analog inhibitor of influenza virus neuraminidase (NA). Replacement of the hydroxyl at the C9 position in DANA and 4-amino-DANA with an amine group, with the intention of taking advantage of an increased electrostatic interaction with a conserved acidic group in the active site to improve inhibitor binding, significantly reduces the inhibitor activity of both compounds. The three-dimensional X-ray structure of the complexes of these ligands and NA was obtained to 1.4 A resolution and showed that both ligands bind isosterically to DANA. Analysis of the geometry of the ammonium at the C4 position indicates that Glu119 may be neutral when these ligands bind. A computational analysis of the binding energies indicates that the substitution is successful in increasing the energy of interaction; however, the gains that are made are not sufficient to overcome the energy that is required to desolvate that part of the ligand that comes in contact with the protein.
+The line below this paragraph, {{ABSTRACT_PUBMED_11274459}}, adds the Publication Abstract to the page
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+-->
+{{ABSTRACT_PUBMED_11274459}}
 ==About this Structure==
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 [[Category: Influenza protein]]
 [[Category: Neuraminidase]]
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