1f2x: Difference between revisions

Revision as of 02:29, 1 July 2008

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File:1f2x.png

Template:STRUCTURE 1f2x

STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05

Template:ABSTRACT PUBMED 10864500

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?, Decanniere K, Muyldermans S, Wyns L, J Mol Biol. 2000 Jun 30;300(1):83-91. PMID:10864500

Page seeded by OCA on Tue Jul 1 02:29:19 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05'''
+===STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05===
-==Overview==
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-Grafting the antigen-binding loops onto a human antibody scaffold is a widely used technique to humanise murine antibodies. The success of this approach depends largely on the observation that the antigen-binding loops adopt only a limited number of canonical structures. Identification of the correct canonical structure is therefore essential. Algorithms that predict the main-chain conformation of the hypervariable loops using only the amino acid sequence often provide this information. Here, we describe new canonical loop conformations for the hypervariable regions H1 and H2 as found in single-domain antibody fragments of dromedaries or llama. Although the occurrence of these new loop conformations was not predicted by the algorithms used, it seems that they could occur in human or mouse antigen-binding loops. Their discovery indicates that the currently used set of canonical structures is incomplete and that the prediction algorithms should be extended to include these new structures.
+The line below this paragraph, {{ABSTRACT_PUBMED_10864500}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_10864500}}
 ==About this Structure==
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 [[Category: Wyns, L.]]
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