1ek0: Difference between revisions

Revision as of 00:52, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ek0.png

Template:STRUCTURE 1ek0

GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTIONGPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION

Template:ABSTRACT PUBMED 10756108

About this StructureAbout this Structure

1EK0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis., Esters H, Alexandrov K, Constantinescu AT, Goody RS, Scheidig AJ, J Mol Biol. 2000 Apr 21;298(1):111-21. PMID:10756108

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION'''
+===GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION===
-==Overview==
+<!--
-Ypt/Rab proteins are membrane-associated small GTP-binding proteins which play a central role in the coordination, activation and regulation of vesicle-mediated transport in eukaryotic cells. We present the 1.5 A high-resolution crystal structure of Ypt51 in its active, GppNHp-bound conformation. Ypt51 is an important regulator involved in the endocytic membrane traffic of Saccharomyces cerevisiae. The structure reveals small but significant structural differences compared with H-Ras p21. The effector loop and the catalytic loop are well defined and stabilized by extensive hydrophobic interactions. The switch I and switch II regions form a well-defined epitope for hypothetical effector protein binding. Sequence comparisons between the different isoforms Ypt51, Ypt52 and Ypt53 provide the first insights into determinants for specific effector binding and for fine-tuning of the intrinsic GTP-hydrolysis rate.
+The line below this paragraph, {{ABSTRACT_PUBMED_10756108}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_10756108}}
 ==About this Structure==
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 [[Category: Vesicular traffic]]
 [[Category: Ypt/rab protein]]
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