1eb2: Difference between revisions

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[[Image:1eb2.jpg|left|200px]]
{{Seed}}
[[Image:1eb2.png|left|200px]]


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{{STRUCTURE_1eb2|  PDB=1eb2  |  SCENE=  }}  
{{STRUCTURE_1eb2|  PDB=1eb2  |  SCENE=  }}  


'''TRYPSIN INHIBITOR COMPLEX (BPO)'''
===TRYPSIN INHIBITOR COMPLEX (BPO)===




==Overview==
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In silico screening of combinatorial libraries prior to synthesis promises to be a valuable aid to lead discovery. PRO_SELECT, a tool for the virtual screening of libraries for fit to a protein active site, has been used to find novel leads against the serine protease factor Xa. A small seed template was built upon using three iterations of library design, virtual screening, synthesis, and biological testing. Highly potent molecules with selectivity for factor Xa over other serine proteases were rapidly obtained.
The line below this paragraph, {{ABSTRACT_PUBMED_11881991}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11881991}}


==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine protease]]
[[Category: Serine protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:53:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:26:08 2008''

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