1e7b: Difference between revisions

Revision as of 00:16, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1e7b.png

Template:STRUCTURE 1e7b

CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC HALOTHANECRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC HALOTHANE

Template:ABSTRACT PUBMED 10940303

About this StructureAbout this Structure

1E7B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures., Bhattacharya AA, Curry S, Franks NP, J Biol Chem. 2000 Dec 8;275(49):38731-8. PMID:10940303

Page seeded by OCA on Tue Jul 1 00:16:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1e7b.jpg|left|200px]]
+{{Seed}}
+[[Image:1e7b.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1e7b|  PDB=1e7b  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC HALOTHANE'''
+===CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC HALOTHANE===
-==Overview==
+<!--
-Human serum albumin (HSA) is one of the most abundant proteins in the circulatory system and plays a key role in the transport of fatty acids, metabolites, and drugs. For many drugs, binding to serum albumin is a critical determinant of their distribution and pharmacokinetics; however, there have as yet been no high resolution crystal structures published of drug-albumin complexes. Here we describe high resolution crystal structures of HSA with two of the most widely used general anesthetics, propofol and halothane. In addition, we describe a crystal structure of HSA complexed with both halothane and the fatty acid, myristate. We show that the intravenous anesthetic propofol binds at two discrete sites on HSA in preformed pockets that have been shown to accommodate fatty acids. Similarly we show that the inhalational agent halothane binds (at concentrations in the pharmacologically relevant range) at three sites that are also fatty acid binding loci. At much higher halothane concentrations, we have identified additional sites that are occupied. All of the higher affinity anesthetic binding sites are amphiphilic in nature, with both polar and apolar parts, and anesthetic binding causes only minor changes in local structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_10940303}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10940303 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10940303}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: General anesthetic]]
 [[Category: Halothane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:45:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:16:14 2008''