1e5t: Difference between revisions

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OCA

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-[[Image:1e5t.jpg|left|200px]]
+{{Seed}}
+[[Image:1e5t.png|left|200px]]
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 {{STRUCTURE_1e5t|  PDB=1e5t  |  SCENE=  }}
-'''PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT'''
+===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, MUTANT===
-==Overview==
+<!--
-Proteases have a variety of strategies for selecting substrates in order to prevent uncontrolled protein degradation. A recent crystal structure determination of prolyl oligopeptidase has suggested a way for substrate selection involving an unclosed seven-bladed beta-propeller domain. We have engineered a disulfide bond between the first and seventh blades of the propeller, which resulted in the loss of enzymatic activity. These results provided direct evidence for a novel strategy of regulation in which oscillating propeller blades act as a gating filter during catalysis, letting small peptide substrates into the active site while excluding large proteins to prevent accidental proteolysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_11256612}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11256612 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11256612}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Prolyl oligopeptidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:42:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:11:48 2008''