1e50: Difference between revisions

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-[[Image:1e50.gif|left|200px]]
+{{Seed}}
+[[Image:1e50.png|left|200px]]
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 {{STRUCTURE_1e50|  PDB=1e50  |  SCENE=  }}
-'''AML1/CBF COMPLEX'''
+===AML1/CBF COMPLEX===
-==Overview==
+<!--
-Mutations in the genes encoding the interacting proteins AML1 and CBFbeta are the most common genetic abnormalities in acute leukaemia, and congenital mutations in the related AML3 gene are associated with disorders of osteogenesis. Furthermore, the interaction of AML1 with CBFbeta is essential for haematopoiesis. We report the 2.6 A resolution crystal structure of the complex between the AML1 Runt domain and CBFbeta, which represents a paradigm for the mode of interaction of this highly conserved family of transcription factors. The structure demonstrates that point mutations associated with cleidocranial dysplasia map to the conserved heterodimer interface, suggesting a role for CBFbeta in osteogenesis, and reveals a potential protein interaction platform composed of conserved negatively charged residues on the surface of CBFbeta.
+The line below this paragraph, {{ABSTRACT_PUBMED_10856244}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10856244 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10856244}}
 ==Disease==
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 [[Category: Williams, R L.]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:40:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:09:32 2008''